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Protective effect of pyrroloquinoline quinone against Aβ-induced neurotoxicity in human neuroblastoma SH-SY5Y cells
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhang, Jun-Jing Zhang, Rui-Fang Meng, Xing-Kai |
| Copyright Year | 2009 |
| Abstract | The neurotoxicity of aggregated beta-amyloid (Abeta) has been implicated as a critical cause in the pathogenesis of Alzheimer's disease (AD). It can cause neurotoxicity in AD by evoking a cascade of oxidative damage-dependent apoptosis to neurons. In the present study, we for the first time investigated the protective effect of pyrroloquinoline quinone (PQQ), an anionic, water soluble compound that acts as a redox cofactor of bacterial dehydrogenases, on Abeta-induced SH-SY5Y cytotoxicity. Abeta(25-35) significantly reduced cell viability, increased the number of apoptotic-like cells, and increased ROS production. All of these phenotypes induced by Abeta(25-35) were markedly reversed by PQQ. PQQ pretreatment recovered cells from Abeta(25-35)-induced cell death, prevented Abeta(25-35)-induced apoptosis, and decreased ROS production. PQQ strikingly decreased Bax/Bcl-2 ratio, and suppressed the cleavage of caspase-3. These results indicated that PQQ could protect SH-SY5Y cells against beta-amyloid induced neurotoxicity. |
| Starting Page | 165 |
| Ending Page | 169 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.neulet.2009.08.037 |
| PubMed reference number | 19699263 |
| Journal | Medline |
| Volume Number | 464 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0304394009011124 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0304394009011124?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.neulet.2009.08.037 |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
