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Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue
| Content Provider | Semantic Scholar |
|---|---|
| Author | Fatykhova, Diana Rabes, Anne Machnik, Christoph Guruprasad, Kunchur Pache, Florence Berg, Johanna Dielmann-Von Toennies, Mario Bauer, Torsten T. Schneider, Paul Schimek, Maria Eggeling, Stephan Mitchell, Timothy J. Mitchell, Andrea M. Hilker, Rolf Hain, Torsten Suttorp, Norbert Hippenstiel, Stefan Hocke, Andreas Opitz, Bastian |
| Copyright Year | 2015 |
| Abstract | Streptococcus pneumoniae is a major cause of pneumonia, sepsis and meningitis. The pore-forming toxin pneumolysin is a key virulence factor of S. pneumoniae, which can be sensed by the NLRP3 inflammasome. Among the over 90 serotypes, serotype 1 pneumococci (particularly MLST306) have emerged across the globe as a major cause of invasive disease. The cause for its particularity is, however, incompletely understood. We therefore examined pneumococcal infection in human cells and a human lung organ culture system mimicking infection of the lower respiratory tract. We demonstrate that different pneumococcal serotypes differentially activate inflammasome-dependent IL-1β production in human lung tissue and cells. Whereas serotype 2, 3, 6B, 9N pneumococci expressing fully haemolytic pneumolysins activate NLRP3 inflammasome-dependent responses, serotype 1 and 8 strains expressing non-haemolytic toxins are poor activators of IL-1β production. Accordingly, purified haemolytic pneumolysin but not serotype 1-associated non-haemolytic toxin activates strong IL-1β production in human lungs. Our data suggest that the evasion of inflammasome-dependent innate immune responses by serotype 1 pneumococci might contribute to their ability to cause invasive diseases in humans. |
| File Format | PDF HTM / HTML |
| DOI | 10.1371/journal.pone.0137108 |
| PubMed reference number | 26317436 |
| Journal | Medline |
| Volume Number | 10 |
| Alternate Webpage(s) | http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0137108&type=printable |
| Alternate Webpage(s) | http://ftp.ncbi.nlm.nih.gov/pub/pmc/c1/43/pone.0137108.PMC4552725.pdf |
| Alternate Webpage(s) | https://doi.org/10.1371/journal.pone.0137108 |
| Journal | PloS one |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
