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Green Synthesis and Antibacterial Activity of 3‐(3‐Aryl[1,8]naphthyridin‐2‐yl)‐7‐[1‐ [1,4‐dioxo‐1,2,3,4‐tetrahydro‐6‐phthalazinyl] ‐2,2,2‐trifluoro‐1‐(trifluoromethyl)ethyl]‐2‐(3‐aryl [1,8]naphthyridin‐2‐yl)# ‐2,2,3,4‐tetrahydro‐1,4‐phthalazinediones.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mogilaiah, K. Rao, Anipindi Nageswara Rao, Peta Koteswara |
| Copyright Year | 2015 |
| Abstract | A simple and highly efficient procedure has been described for the synthesis of 3-(3-aryl[1,8]naphthyridin-2-yl)-7-[1-[1,4-dioxo1, 2, 3, 4-tetrahydro-6-phthalazinyl]-2, 2, 2-trifluoro-1-(trifluoromethyl)ethyl]-2-(3-aryl[1,8]naphthyridin-2-yl)-1,2,3,4-tetrahydro1,4-phthalazinediones 3 by the condensation of 3-aryl-2hydrazino-1,8-naphthyridines 1 with 4,4′-(hexafluoroisopropylidene)diphthalic anhydride 2 in 2:1 molar ratio in the presence of catalytic amount of DMF under microwave irradiation/ in presence of catalytic amount of PTSA in the solid state at RT under grinding conditions. The products have been obtained in very good yields and in a state of high purity. The structures of the compounds 3 have been established on the basis of their spectral (IR and H NMR) and analytical data. The compounds 3 have been screened for their antibacterial activity. |
| File Format | PDF HTM / HTML |
| DOI | 10.1002/chin.201522208 |
| Volume Number | 46 |
| Alternate Webpage(s) | http://nopr.niscair.res.in/bitstream/123456789/30321/1/IJCB%2054B(1)%20135-138.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |