NDLI: Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation.

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Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation.

Content Provider	Semantic Scholar
Author	Berberich, S. Punnakkal, Pradeep Jensen, Vidar R. Pawlak, Verena Seeburg, P. H. Hvalby, Øivind Köhr, Georg
Copyright Year	2005
Abstract	NMDA receptor (NMDAR) 2A (NR2A)- and NR2B-type NMDARs coexist in synapses of CA1 pyramidal cells. Recent studies using pharmacological blockade of NMDAR subtypes proposed that the NR2A type is responsible for inducing long-term potentiation (LTP), whereas the NR2B type induces long-term depression (LTD). This contrasts with the finding in genetically modified mice that NR2B-type NMDARs induce LTP when NR2A signaling is absent or impaired, although compensatory mechanisms might have contributed to this result. We therefore assessed the contribution of the two NMDAR subtypes to LTP in mouse hippocampal slices by different induction protocols and in the presence of NMDAR antagonists, including the NR2A-type blocker NVP-AAM077, for which an optimal concentration for subtype selectivity was determined on recombinant and native NMDARs. Partial blockade of NMDA EPSCs by 40%, either by preferentially antagonizing NR2A- or NR2B-type NMDARs or by the nonselective antagonist D-AP-5, did not impair LTP, demonstrating that hippocampal LTP induction can be generated by either NMDAR subtype.
File Format	PDF HTM / HTML
DOI	10.1523/JNEUROSCI.1905-05.2005
PubMed reference number	16033900
Journal	Medline
Volume Number	25
Issue Number	29
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/25/29/6907.full.pdf
Alternate Webpage(s)	https://doi.org/10.1523/JNEUROSCI.1905-05.2005
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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