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Sleep-disordered breathing and myocardial ischemia in patients with coronary artery disease.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mooe, Thomas Franklin, Karl Anders Wiklund, Urban Rabben, Terje |
| Copyright Year | 2000 |
| Abstract | STUDY OBJECTIVES To examine the occurrence of nocturnal myocardial ischemia and its relationship to sleep-disordered breathing (apneas and oxygen desaturations) in randomly selected men and women undergoing coronary angiography because of angina pectoris. DESIGN An observational study using an overnight sleep study and Holter recording to examine disordered breathing (oxyhemoglobin desaturations > or = 4% and apnea-hypopneas), heart rates, and ST-segment depressions (> or = 1 mm, > or = 1 min). SETTING University Hospital, Umeå, a teaching hospital in northern Sweden. PATIENTS One hundred thirty-two men and 94 women referred for consideration of coronary intervention were randomly included, by lot. RESULTS ST-segment depressions occurred in 59% (134 of 226) of the patients, and nocturnal ST-segment depressions occurred in 31% (69 of 226). A ST-segment depression occurred within 2 min after an apnea-hypopnea or desaturation in 12% (27 of 226) of patients. This temporal association was seen in 19% of nocturnal ST-segment depressions (71 of 366), more frequently in men (p < 0.01) and in more severely disordered breathing (p < 0.001). Most of these ST-segment depressions were preceded by a series of breathing events: three or more apnea-hypopneas or desaturations or both in 70% (50 of 71). CONCLUSION Episodes of nocturnal myocardial ischemia are common in patients with angina pectoris. However, a temporal relationship between sleep-disordered breathing and myocardial ischemia is present only in a minority of the patients, but occurs more frequently in men and in more severely disordered breathing. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://journal.publications.chestnet.org/pdfaccess.ashx?url=/data/journals/chest/21948/1597.pdf |
| PubMed reference number | 10858389v1 |
| Volume Number | 117 |
| Issue Number | 6 |
| Journal | Chest |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Angina Pectoris Arteriopathic disease Coronary Artery Disease Coronary angiography Depressive disorder Fifty Nine Myocardial Ischemia Oxygen Oxyhemoglobin device Patients Polysomnography Sixty Nine Sleep Apnea Syndromes Teaching Hospitals angiogram heart rate |
| Content Type | Text |
| Resource Type | Article |
