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F-18 fluorodeoxy-D-glucose positron emission tomography scan in the initial evaluation of patients with a primary melanoma thicker than 4 mm
| Content Provider | Semantic Scholar |
|---|---|
| Author | Maubec, Eve Lumbroso, Jean Masson, Florence Suciu, Voichita Kolb, F. Christopher Mamelle, Gérard Cavalcanti, Andréa Boitier, Françoise Spatz, Alain Aupérin, Anne Leboulleux, Sophie Avril, Marie-Françoise |
| Copyright Year | 2007 |
| Abstract | Metabolic imaging with F-18 fluorodeoxy-D-glucose positron emission tomography is one of the most sensitive and non-invasive techniques, and has proved useful in melanoma. We designed, in 2004, at the Institute Gustave Roussy, a prospective study to determine the value of F-18 fluorodeoxy-D-glucose positron emission tomography scanning in the detection of regional and/or distant metastasis in 25 new patients referred for the treatment of a primary melanoma thicker than 4 mm (tumor node metastases stage T4). The sentinel lymph node biopsy was proposed for all the patients without a palpable regional lymph node. Abnormal positron emission tomography scan findings were correlated to available histological data and to the course of the disease. The F-18 fluorodeoxy-D-glucose positron emission tomography scan identified 0/2 intact primary melanomas, 1/4 residual primary melanomas after limited excision, 0/6 lymph node basins with micrometastasis, 4/4 lymph node basins with enlarged palpable lymph nodes and 0 distant metastasis. The sensitivity and specificity of positron emission tomography scans for microscopic lymph node disease in basins were, respectively, 0 and 92%. A false-positive F-18 fluorodeoxy-D-glucose positron emission tomography result in a cervical basin led to a useless cervical lymph node dissection. In three patients, the positron emission tomography scan was positive in distant sites but none of these foci represented a true metastasis.In conclusion, it is not useful to include a positron emission tomography scan in the initial work-up of patients with primary melanoma, even in patients with thick primary melanomas (>4 mm). Sentinel lymph node biopsy remains the technique of choice for the most accurate initial staging. |
| Starting Page | 147 |
| Ending Page | 154 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1097/CMR.0b013e32815c10b0 |
| Alternate Webpage(s) | http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.547.9928&rep=rep1&type=pdf |
| PubMed reference number | 17505260 |
| Alternate Webpage(s) | https://doi.org/10.1097/CMR.0b013e32815c10b0 |
| Journal | Medline |
| Volume Number | 17 |
| Journal | Melanoma research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
