NDLI: Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils.

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Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils.

Content Provider	Semantic Scholar
Author	Bieschke, Jan Herbst, Martin Wiglenda, Thomas Friedrich, Ralf Boeddrich, Annett Schiele, Franziska Kleckers, Daniela Amo, Juan Miguel López Del Grüning, Björn A. Wang, Qinwen Schmidt, Michael Rosendahl Lurz, Rudi Anwyl, Roger Schnoegl, Sigrid Fändrich, Marcus Frank, R. Fronczek Reif, Bernd Guenther, Stefan Walsh, Dominic M. Wanker, Erich E.
Copyright Year	2011
Abstract	Several lines of evidence indicate that prefibrillar assemblies of amyloid-β (Aβ) polypeptides, such as soluble oligomers or protofibrils, rather than mature, end-stage amyloid fibrils cause neuronal dysfunction and memory impairment in Alzheimer's disease. These findings suggest that reducing the prevalence of transient intermediates by small molecule-mediated stimulation of amyloid polymerization might decrease toxicity. Here we demonstrate the acceleration of Aβ fibrillogenesis through the action of the orcein-related small molecule O4, which directly binds to hydrophobic amino acid residues in Aβ peptides and stabilizes the self-assembly of seeding-competent, β-sheet-rich protofibrils and fibrils. Notably, the O4-mediated acceleration of amyloid fibril formation efficiently decreases the concentration of small, toxic Aβ oligomers in complex, heterogeneous aggregation reactions. In addition, O4 treatment suppresses inhibition of long-term potentiation by Aβ oligomers in hippocampal brain slices. These results support the hypothesis that small, diffusible prefibrillar amyloid species rather than mature fibrillar aggregates are toxic for mammalian cells.
Starting Page	93
Ending Page	101
Page Count	9
File Format	PDF HTM / HTML
DOI	10.1038/nchembio.719
PubMed reference number	22101602
Journal	Medline
Volume Number	8
Issue Number	1
Alternate Webpage(s)	http://edoc.mdc-berlin.de/11914/2/11914suppl.pdf
Alternate Webpage(s)	http://edoc.mdc-berlin.de/11914/1/11914oa.pdf
Alternate Webpage(s)	https://doi.org/10.1038/nchembio.719
Journal	Nature chemical biology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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