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Protective effects of [6]-paradol on histological lesions and immunohistochemical gene expression in DMBA induced hamster buccal pouch carcinogenesis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mariadoss, Arokia Vijayaanand Kathiresan, Suresh Muthusamy, Rajasekar Kathiresan, Sivakumar |
| Copyright Year | 2013 |
| Abstract | BACKGROUND The search for naturally occurring agents in routinely consumed foods that may inhibit cancer development is of high priority. [6]-Paradol is a pungent phenolic bioactive component from ginger with well- documented health promoting antioxidant, antimutagenic, antigenotoxic and anti-inflammatory properties. However, anticarcinogenic effects have yet to be fully explored. The objectives of the present study were therefore to assess protective effects against 7,12-dimethylbenz(a)anthracene (DMBA) induced buccal pouch carcinogenesis in male golden Syrian hamsters. METHODS Oral squamous cell carcinomas developed in the left buccal pouch of hamsters on painting with 0.5% of DMBA, three times in a week. To assess the apoptotic associated gene expressing potential of [6]-paradol, it was orally administered to DMBA treated hamsters on alternate days from DMBA painting for 14 weeks. RESULTS We observed 100% tumor formation with marked levels of neoplastic changes and altered the expression of apoptotic associated gene (p53, bcl-2, caspase-3 and TNF-α) was observed in the DMBA alone painted hamsters as compared to control hamsters. Oral administration of [6]-paradol at a dose of 30 mg/kg b.wt to DMBA treated animals on alternative days for 14 weeks significantly reduced the neoplastic changes and improved the status of apoptosis associated gene expression. CONCLUSION These observations confirmed that [6]-paradol acts as a tumor suppressing agent against DMBA induced oral carcinogenesis. We also conclude that [6]-paradol also effectively enhances apoptosis- associated gene expression in DMBA treated animals. |
| File Format | PDF HTM / HTML |
| DOI | 10.7314/APJCP.2013.14.5.3123 |
| PubMed reference number | 23803090 |
| Journal | Medline |
| Volume Number | 14 |
| Issue Number | 5 |
| Alternate Webpage(s) | http://journal.waocp.org/article_27754_b31096a358407037e2b6b25d864bb71c.pdf |
| Alternate Webpage(s) | https://doi.org/10.7314/APJCP.2013.14.5.3123 |
| Journal | Asian Pacific journal of cancer prevention : APJCP |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
