NDLI: The spindle pole body plays a key role in controlling mitotic commitment in the fission yeast Schizosaccharomyces pombe.

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The spindle pole body plays a key role in controlling mitotic commitment in the fission yeast Schizosaccharomyces pombe.

Content Provider	Semantic Scholar
Author	Hagan, Iain M.
Copyright Year	2008
Abstract	Commitment to mitosis is regulated by a conserved protein kinase complex called MPF (mitosis-promoting factor). MPF activation triggers a positive-feedback loop that further promotes the activity of its activating phosphatase Cdc25 and is assumed to down-regulate the MPF-inhibitory kinase Wee1. Four protein kinases contribute to this amplification loop: MPF itself, Polo kinase, MAPK (mitogen-activated protein kinase) and Greatwall kinase. The fission yeast SPB (spindle pole body) component Cut12 plays a critical role in modulating mitotic commitment. In this review, I discuss the relationship between Cut12 and the fission yeast Polo kinase Plo1 in mitotic control. These results indicate that commitment to mitosis is co-ordinated by control networks on the spindle pole. I then describe how the Cut12/Plo1 control network links growth control signalling from TOR (target of rapamycin) and MAPK networks to the activation of MPF to regulate the timing of cell division.
Starting Page	411
Ending Page	411
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.biochemsoctrans.org/content/ppbiost/36/5/1097.full.pdf
PubMed reference number	18793196v1
Alternate Webpage(s)	https://doi.org/10.1042/BST0361097
DOI	10.1042/bst0361097
Journal	Biochemical Society transactions
Volume Number	36
Part	5
Language	English
Access Restriction	Open
Subject Keyword	Assumed Cell division Maturation-Promoting Factor Mitogen-Activated Protein Kinases Mitosis Precipitating Factors Promotion (action) Schizosaccharomyces pombe Sirolimus Spindle Pole Body Spindle Poles biological signaling mmf1 protein, S pombe
Content Type	Text
Resource Type	Article

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