Loading...
Please wait, while we are loading the content...
Similar Documents
Calcineurin controls inositol 1,4,5-trisphosphate type 1 receptor expression in neurons.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Genazzani, Armando A. Carafoli, Ernesto Guerini, Danilo |
| Copyright Year | 1999 |
| Abstract | In the central nervous system, release of Ca2+ from intracellular stores contributes to numerous functions, including neurotransmitter release and long-term potentiation and depression. We have investigated the developmental profile and the regulation of inositol 1,4,5-trisphosphate receptor (IP3R) and ryanodine receptor (RyR) in primary cultures of cerebellar granule cells. The expression of both receptor types increases during development. Whereas the expression of type 1 IP3R appears to be regulated by Ca2+ influx through L type channels or N-methyl-D-aspartate (NMDA) receptors, RyR levels increase independently of Ca2+. The main target of Ca2+-influx-regulating IP3R expression is the Ca2+ calmodulin-dependent protein phosphatase calcineurin, because pharmacological blockade of this protein abolishes IP3R expression. Although calcineurin has been shown to regulate the phosphorylation state of the IP3R, the effect described here is at the transcriptional level because IP3R mRNA changes in parallel with protein levels. Thus, calcineurin plays a dual role in IP3R-mediated Ca2+ signaling: it regulates IP3R function by dephosphorylation in the short-term time scale and IP3R expression over more extended periods. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.pnas.org/content/96/10/5797.full.pdf |
| PubMed reference number | 10318964v1 |
| Volume Number | 96 |
| Issue Number | 10 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Aspartic Acid CNS disorder Calcineurin Calcium ion Calmodulin Depressive disorder Dual Inositol 1,4,5-Trisphosphate Long-Term Potentiation N-Methylaspartate Neurotransmitters Pharmacology Protein dephosphorylation Protein phosphatase RYR1 gene Ryanodine Receptor Calcium Release Channel Transcription, Genetic chemosensitization/potentiation ryanodine receptor complex location |
| Content Type | Text |
| Resource Type | Article |
