NDLI: siRNA liposome-gold nanorod vectors for multispectral optoacoustic tomography theranostics.

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siRNA liposome-gold nanorod vectors for multispectral optoacoustic tomography theranostics.

Content Provider	Semantic Scholar
Author	Taruttis, Adrian Lozano, Neus Nunes, Antonio Jasim, Dhifaf A. Beziere, Nicolas Herzog, Eva Kostarelos, Kostas Ntziachristos, Vasilis
Copyright Year	2014
Abstract	Therapeutic applications of gene silencing using siRNA have seen increasing interest over the past decade. The optimization of the delivery and biodistribution of siRNA using liposome-gold nanorod (AuNRs) nanoscale carriers can greatly benefit from adept imaging methods that can visualize the time-resolved delivery performance of such vectors. In this work, we describe the effect of AuNR length incorporated with liposomes and show their complexation with siRNA as a novel gene delivery vehicle. We demonstrate the application of multispectral optoacoustic tomography (MSOT) to longitudinally visualize the localisation of siRNA carrying liposome-AuNR hybrids within tumors. Combination of in vivo MSOT with ex vivo fluorescence cryo-slice imaging offers further insight into the siRNA transport and activity obtained.
File Format	PDF HTM / HTML
DOI	10.1039/c4nr04164j
Alternate Webpage(s)	http://www.nanomedicinelab.com/wp-content/uploads/2014/10/Nanoscale_22_14.pdf
Alternate Webpage(s)	http://pubs.rsc.org/en/content/getauthorversionpdf/C4NR04164J
PubMed reference number	25301102
Alternate Webpage(s)	https://doi.org/10.1039/c4nr04164j
Journal	Medline
Volume Number	6
Issue Number	22
Journal	Nanoscale
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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