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Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury-outcomes at 6 months.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Edwards, Phil Arango, Miguel F. Balica, Laura Cottingham, Rowland El-Sayed, Hesham Farrell, Barbara Fernandes, Janice Gogichaisvili, Tamar Golden, Nyoman Hartzenberg, Bennie H. Husain, Mazhar Ulloa, Mario Izurieta Jerbi, Zouheir Khamis, Hussein Sami Komolafe, Edward Oluwole Laloë, Véronique Lomas, Gabrielle Ludwig, Silke Mazairac, Guy Sanchéz, Maria De Los Angeles Muñoz Nasi, Luis Antônio Olldashi, Fatos Plunkett, Patrick Roberts, Ian Sandercock, Peter Ag Shakur, Haleema Soler, Caridad Stocker, Reto Svoboda, Petr Trenkler, Stefan Venkataramana, Neelam Krishnan Wasserberg, Jonathan Yates, John Yutthakasemsunt, Surakrant |
| Copyright Year | 2005 |
| Abstract | MRC CRASH is a randomised controlled trial (ISRCTN74459797) of the effect of corticosteroids on death and disability after head injury. We randomly allocated 10,008 adults with head injury and a Glasgow Coma Scale score of 14 or less, within 8 h of injury, to a 48-h infusion of corticosteroid (methylprednisolone) or placebo. Data at 6 months were obtained for 9673 (96.7%) patients. The risk of death was higher in the corticosteroid group than in the placebo group (1248 [25.7%] vs 1075 [22.3%] deaths; relative risk 1.15, 95% CI 1.07-1.24; p=0.0001), as was the risk of death or severe disability (1828 [38.1%] vs 1728 [36.3%] dead or severely disabled; 1.05, 0.99-1.10; p=0.079). There was no evidence that the effect of corticosteroids differed by injury severity or time since injury. These results lend support to our earlier conclusion that corticosteroids should not be used routinely in the treatment of head injury. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.ccmpitt.com/ebm/trauma/final%20results%20of%20mrc%20crash_randomized%20placebo%20controlled%20trial%20of%20intravenous%20corticosteroid%20in%20adults%20with%20head%20injury%20outcomes%20at%206%20months.pdf |
| PubMed reference number | 15936423v1 |
| Volume Number | 365 |
| Issue Number | 9475 |
| Journal | Lancet |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adrenal Cortex Hormones Cessation of life Comatose Craniocerebral Trauma Disabled Persons Hyperglycemic Hyperosmolar Nonketotic Coma Methylprednisolone Patients |
| Content Type | Text |
| Resource Type | Article |
