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Tangeretin inhibits extracellular-signal-regulated kinase (ERK) phosphorylation.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Slambrouck, Severine Van Parmar, Virinder S. Sharma, Sunil K. Bondt, Bart De Foré, Fleur Coopman, Peter J. Vanhoecke, Barbara W. A. Boterberg, Tom Depypere, Herman T. Leclercq, Guy Bracke, Marc E. |
| Copyright Year | 2005 |
| Abstract | Tangeretin is a methoxyflavone from citrus fruits, which inhibits growth of human mammary cancer cells and cytolysis by natural killer cells. Attempting to unravel the flavonoid's action mechanism, we found that it inhibited extracellular-signal-regulated kinases 1/2 (ERK1/2) phosphorylation in a dose- and time-dependent way. In human T47D mammary cancer cells this inhibition was optimally observed after priming with estradiol. The spectrum of the intracellular signalling kinase inhibition was narrow and comparison of structural congeners showed that inhibition of ERK phosphorylation was not unique for tangeretin. Our data add tangeretin to the list of small kinase inhibitors with a restricted intracellular inhibition profile. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.febslet.2004.10.114 |
| Alternate Webpage(s) | https://core.ac.uk/download/pdf/82601805.pdf |
| PubMed reference number | 15757658 |
| Alternate Webpage(s) | https://doi.org/10.1016/j.febslet.2004.10.114 |
| Journal | Medline |
| Volume Number | 579 |
| Issue Number | 7 |
| Journal | FEBS letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
