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Pathogenic Th2 (Tpath2) cells in airway inflammation
| Content Provider | Semantic Scholar |
|---|---|
| Author | Endo, Yusuke Nakayama, Toshinori |
| Copyright Year | 2015 |
| Abstract | Immunological memory is a hallmark of adaptive immunity. Memory CD4 T cells function as a control tower of the adaptive immune system to direct immune responses, leading to the elimination of various invaded microorganisms. Important roles of functionally distinct CD4 helper T cell (Th) subsets, such as Th1, Th2 and Th17 cells, in the host-defense immune responses have been well recognized. In addition, however, these Th cell subsets are known to be involved in the pathogenesis of various chronic inflammatory diseases, including asthma. We recently identified an IL-5-producing highly pathogenic population in memory Th2 cells in allergic asthma [1, 2]. We named this population “memory-type pathogenic Th2 (Tpath2) cells” in airway inflammation. Other investigators also reported distinct Th2 cell populations, which produce a substantial amount of IL-5 or multiple cytokines in addition to IL-4 and IL-13 [3, 4]. These populations appear to be responsible for the pathology of various Th2-type chronic inflammatory diseases. |
| Starting Page | 32303 |
| Ending Page | 32304 |
| Page Count | 2 |
| File Format | PDF HTM / HTML |
| DOI | 10.18632/oncotarget.6033 |
| PubMed reference number | 26459386 |
| Journal | Medline |
| Volume Number | 6 |
| Alternate Webpage(s) | http://www.oncotarget.com/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=6033&path%5B%5D=14670 |
| Alternate Webpage(s) | http://ftp.ncbi.nlm.nih.gov/pub/pmc/d5/d5/oncotarget-06-32303.PMC4741689.pdf |
| Alternate Webpage(s) | https://doi.org/10.18632/oncotarget.6033 |
| Journal | Oncotarget |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
