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Combination of pentamidine and trimethoprim-sulfamethoxazole in therapy of Pneumocystis carinii pneumonia in rats.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kluge, Ronica M. Spaulding, Dayton Mathewson Spain, Aremelle |
| Copyright Year | 1978 |
| Abstract | Treatment with either pentamidine isethionate or trimethoprim-sulfamethoxazole significantly reduces the mortality of Pneumocystis carinii pneumonia. It is not known whether a combination might act in an additive, synergistic, or antagonistic manner. We studied the interaction of these two agents in the steroid-conditioned rat model of pneumocystosis. Of animals receiving pentamidine alone, 48% died and 45% had P. carinii cysts at autopsy. Trimethoprim-sulfamethoxazole alone resulted in 21% mortality, and cysts were found in 28%. Both agents in full doses resulted in 45% deaths and cysts in 37%. Animals treated with half-dosages of pentamidine plus trimethroprim-sulfamethoxazole had mortality of 35%, and 21% had cysts. Trimethoprim alone, in two dosages, was ineffective in eradicating P. carinii cysts. The data suggest that combination therapy is no more effective than trimethoprim-sulfamethoxazole alone in the treatment of P. carinii pneumonia. |
| File Format | PDF HTM / HTML |
| DOI | 10.1128/AAC.13.6.975 |
| PubMed reference number | 307941 |
| Journal | Medline |
| Volume Number | 13 |
| Issue Number | 6 |
| Alternate Webpage(s) | http://aac.asm.org/content/13/6/975.full.pdf |
| Alternate Webpage(s) | https://doi.org/10.1128/AAC.13.6.975 |
| Journal | Antimicrobial agents and chemotherapy |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
