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odi fi ed rhodamine-based fl uorescent probe for in vitro / vivo imaging of gold ions †
| Content Provider | Semantic Scholar |
|---|---|
| Author | Karakuş, Erman Cakan-Akdoganb, Gulcin Emrullahoğlu, Mustafa |
| Copyright Year | 2015 |
| Abstract | Ionic gold species facilitate remarkable chemical and biological activities. Recently, using gold as a catalyst has attracted great interest in the eld of synthetic chemistry. Yet, along with their synthetic utility, gold species exert diverse biological effects on human health, ranging from disease treatment to organ damage. Drugs based on certain gold-ion complexes can be used to treat various human diseases, including asthma, cancer, and rheumatoid arthritis, among other autoimmune diseases. However, in sharp contrast to their benecial effects, gold ions also have the potential to disturb a range of biological processes as they bind strongly to biomolecules, thereby causing serious health problems and damage to organs. The design and development of molecular tools for detecting biologically important target species is an alluring subject of research in the area of chemosensing and molecular imaging. Apart from the biological signicance of gold ions, the focus of recent research has been on the development of probes that can simply identify gold species in the living milieu. Lately, we and also other researchers have devised a series of molecular sensors that proved highly efficient in monitoring gold ions in chemical and biological environments. Given their impressive photophysical properties, uorescent molecules such as rhodamine, boron-dipyrromethene (BODIPY), uorescein and naphthalimide are most commonly employed as signal transducers. Notably, the great majority of those probes use an alkyne motif as a gold ion-recognition site and benet from the strong alkyne affinity of gold ions to modulate an optical signal. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://openaccess.iyte.edu.tr/bitstream/handle/11147/5966/5966.pdf?isAllowed=y&sequence=1 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
