Loading...
Please wait, while we are loading the content...
Immunoglobulin variable-region-like domains of diverse sequence within the major histocompatibility complex of the chicken.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Miller, Marcia M. Goto, Rieko Young, Sandra Chirivella, Javier Hawke, Dj Miyada, Charles Garrett |
| Copyright Year | 1991 |
| Abstract | The highly polymorphic B-G antigens are considered to be part of the major histocompatibility complex (MHC) of the chicken, the B system of histocompatibility, because they are encoded in a family of genes tightly linked with the genes encoding MHC class I and class II antigens. To better understand these unusual MHC antigens, full-length B-G cDNA clones were isolated from B21 embryonic erythroid cell cDNA library, restriction-mapped, and sequenced. Five transcript types were identified. Analysis of the deduced amino acid sequences suggests that the B-G polypeptides are composed of single extracellular domains that resemble immunoglobulin domains of the variable-region (V) type, single membrane-spanning domains typical of integral membrane proteins, and long cytoplasmic tails. Sequence diversity among the five transcript types was found in all domains, notably including the B-G immunoglobulin V-like domains. The cytoplasmic tails of the B-G antigens are made up entirely of units of seven amino acid residues (heptads) that are typical of an alpha-helical coiled-coil conformation. The heptads vary in number and sequence between the different transcripts. The presence within B-G polypeptides of polymorphic immunoglobulin V-like domains warrants further investigations to determine the degree and nature of variability within this domain in these unusual MHC antigens. |
| File Format | PDF HTM / HTML |
| DOI | 10.1073/pnas.88.10.4377 |
| Alternate Webpage(s) | http://www.pnas.org/content/88/10/4377.full.pdf |
| PubMed reference number | 1903541 |
| Alternate Webpage(s) | https://doi.org/10.1073/pnas.88.10.4377 |
| Journal | Medline |
| Volume Number | 88 |
| Issue Number | 10 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
