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A Novel Technique for the Assessment of Preoperative Cardiovascular Risk: Reactive Hyperemic Response to Short-Term Exercise
| Content Provider | Semantic Scholar |
|---|---|
| Author | Schier, Robert Hinkelbein, Jochen Marcus, Hanke E. Smallwood, Ashley K. Correa, Arlene M. Mehran, Reza John El-Zein, Randa Riedel, Bernhard J. |
| Copyright Year | 2013 |
| Abstract | BACKGROUND Perioperative vascular function has been widely studied using noninvasive techniques that measure reactive hyperemia as a surrogate marker of vascular function. However, studies are limited to a static setting with patients tested at rest. We hypothesized that exercise would increase reactive hyperemia as measured by digital thermal monitoring (DTM) in association to patients' cardiometabolic risk. METHODS Thirty patients (58 ± 9 years) scheduled for noncardiac surgery were studied prospectively. Preoperatively, temperature rebound (TR) following upper arm cuff occlusion was measured before and 10 minutes after exercise. Data are presented as means ± SD. Statistical analysis utilized ANOVA and Fisher's exact test, with P values <0.05 regarded as significant. RESULTS Following exercise, TR-derived parameters increased significantly (absolute: 0.53 ± 0.95 versus 0.04 ± 0.42°C, P=0.04, and % change: 1.78 ± 3.29 versus 0.14 ± 1.27 %, P=0.03). All patients with preoperative cardiac risk factors had a change in TR (after/before exercise, ΔTR) with values falling in the lower two tertiles of the study population (ΔTR <1.1%). CONCLUSION Exercise increased the reactive hyperemic response to ischemia. This dynamic response was blunted in patients with cardiac risk factors. The usability of this short-term effect for the preoperative assessment of endothelial function warrants further study. |
| File Format | PDF HTM / HTML |
| DOI | 10.1155/2013/837130 |
| PubMed reference number | 23691513 |
| Journal | Medline |
| Volume Number | 2013 |
| Alternate Webpage(s) | http://www.endothelix.com/pdf/DTM_PreopCVrisk_response-to-short-term-exercise_2013.pdf |
| Alternate Webpage(s) | http://ftp.ncbi.nlm.nih.gov/pub/pmc/eb/1d/BMRI2013-837130.PMC3652140.pdf |
| Alternate Webpage(s) | http://downloads.hindawi.com/journals/bmri/2013/837130.pdf |
| Alternate Webpage(s) | http://www.endothelix.com/pdf/reactive-hyperemic-response-to-short-term-exercise.pdf |
| Alternate Webpage(s) | https://doi.org/10.1155/2013%2F837130 |
| Journal | BioMed research international |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
