NDLI: Coronoary Autoregulation Based on Oxygen Flow : a Model of Oxygen Supply to Coronary Arteriolar Smooth Muscle in Injury and Endothelial Dysfunction

Content Provider	Semantic Scholar
Author	Sheffer, N. Scheinowitz, Mickey Barnea, Ofer
Copyright Year	2001
Abstract	A multi-layers theoretical model of a coronary arteriolar smooth muscle was developed to elucidate the role of oxygen in the control of coronary blood flow. Both oxygen transport by diffusion and local tissue metabolism were considereded. Oxygen partial pressure in all layers was calculated. The model sugggets that in normal conditions, oxygen partial pressure reaches its minimal value in the media, where oxygen consumption is the greatest. When the smooth muscle is injured, its metabolic demands are increased in order to heal, resulting in a PO2 decline. These results are in agreement with experimental results. The model also shows that increased myocardial oxygen partial pressure causes the arteriolar smooth muscle to contract in response to lack of oxygen. Decreased myocardial oxygen pressure results in expansion of the arteriole allowing greater coronary flow.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.dtic.mil/get-tr-doc/pdf?AD=ADA411923
Alternate Webpage(s)	http://www.dtic.mil/dtic/tr/fulltext/u2/a411923.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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