Neuropsychological long-term sequelae after posterior fossa tumour resection during childhood.

Content Provider	Semantic Scholar
Author	Steinlin, Maja Imfeld, Sara Zulauf, Prisca Boltshauser, Eugen Lövblad, Karl-Olaf Lüthy, Annette Ridolfi Perrig, Walter Kaufmann, Franz Jos
Copyright Year	2003
Abstract	The importance of the cerebellum for non-motor functions is becoming more and more evident. The influence on cognitive functions from acquired cerebellar lesions during childhood, however, is not well known. We present follow-up data from 24 patients, who were operated upon during childhood for benign cerebellar tumours. The benign histology of these tumours required neither radiotherapy nor chemotherapy. Post-operatively, these children were of normal intelligence with a mean IQ of 99.1, performance intelligence quotient (PIQ) of 101.3 and verbal intelligence quotient (VIQ) of 96.8. However, 57% of patients showed abnormalities in subtesting. In addition, more extensive neuropsychological testing revealed significant problems for attention, memory, processing speed and interference. Visuo-constructive problems were marked for copying the Rey figure, but less pronounced for recall of the figure. Verbal fluency was more affected than design fluency. Behavioural deficits could be detected in 33% of patients. Attention deficit problems were marked in 12.5%, whereas others demonstrated psychiatric symptoms such as mutism, addiction problems, anorexia, uncontrolled temper tantrums and phobia. Age at tumour operation and size of tumour had no influence on outcome. Vermis involvement was related to an increase in neuropsychological and psychiatric problems. The observation that patients with left-sided cerebellar tumours were more affected than patients with right-sided tumours is probably also influenced by a more pronounced vermian involvement in the former group. In summary, this study confirms the importance of the cerebellum for cognitive development and points to the necessity of careful follow-up for these children to provide them with the necessary help to achieve full integration into professional life.
Starting Page	1998
Ending Page	2008
Page Count	11
File Format	PDF HTM / HTML
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PubMed reference number	12876140v1
Volume Number	126
Part	9
Journal	Brain : a journal of neurology
Language	English
Access Restriction	Open
Subject Keyword	Addictive Behavior Anorexia Attention deficit hyperactivity disorder Benign Cerebellar Neoplasms Cerebellar Diseases Cerebellar vermis structure Cognition Disorders Congenital Abnormality Cortical Cell Layer of the Cerebellum Follow-Up Report Infratentorial Neoplasms Intelligence quotient Memory Disorders Mental disorders Munchausen Syndrome Mutism Neuropsychological Tests Patients Phobic anxiety disorder Sequela of disorder Tantrums Therapeutic radiology procedure childhood cerebellar astrocytoma
Content Type	Text
Resource Type	Article