The role of luteinizing hormone-releasing hormone in the diagnosis of constitutional delayed puberty.

Content Provider	Semantic Scholar
Author	Sagel, Jeffrey S. Joffe, Barry Isaac
Copyright Year	1975
Abstract	The presumptive diagnosis of constitutional delayed adolescence is difficult to substantiate. Clinical examination and routine biochemical testing are not sufficient to exclude isolated gonadotrophin deficiency. Seven males are reported who presented with delayed puberty. These patients were given 100 [±g luteinizing hormone-releasing hormone (LH-RH) intravenously, and the luteinizing hormone (LH) and follicle stimulating hormone (FSH) responses were measured. Three of four males who were completely prepubertal (Stage 1) had a normal adult male response. These three patients have progressed further into puberty several months after this diagnostic test. The fourth patient in stage 1 puberty had a prepubertal LH response. A year later the response became adult in type, and 3 months thereafter stage 2 puberty was evident. The LH response to LH-RH thus appears to have some prognostic value in the assessment of males presenting with delayed puberty.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://pmj.bmj.com/content/postgradmedj/51/599/611.full.pdf
PubMed reference number	1105498v1
Volume Number	51
Issue Number	599
Journal	Postgraduate medical journal
Language	English
Access Restriction	Open
Subject Keyword	Delayed Puberty Diagnostic tests Fucosidase Deficiency Disease Gonadorelin Gonadotropins Ovarian Follicle Patients Prepuberty Stage level 1 Stage level 2 Stimulation (motivation)
Content Type	Text
Resource Type	Article