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UvA-DARE ( Digital Academic Repository ) Control analysis of glycolytic oscillations
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bier, Martin Teusink, Bas Kholodenko, Boris N. |
| Copyright Year | 2017 |
| Abstract | The principles involved in the control of the frequency of sustained metabolic oscillations are developed in the conte\t of 4vcoIvtic oscillations in Strccharornvxs crrrl~isine. To this purpose, an existing mathematical model that describes the c< i experimentally obtained oscillations was simplified to a core model. Frequency. relative phase, average concentration\ and amplitudes of the oscillations were well approximated by writing the two remaining metabolic variables of the core model (representing [ATP] and [hexose]) as harmonic functions of time and by requiring them to fulfill the differential equations. The extent to which an enzyme (-conglomerate) controls the frequency in a swtained oscillation is defined as the Iof~~log derivative of that frequency with respect to enzyme activity. In both the full model and the core model this control 01. frequency and the control over the average concentrations proved to be distributed over the ewymeh. WC identified a summation theorem, stating that the sum of such control coefficients over all processes equals unity for l’requcnc! ;uncl xl-cl for the average concentrations. K~~rr.ori/.\’ (‘ontrol analysis: Glycolytic oscillations |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://pure.uva.nl/ws/files/1213336/1561_16350y.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
