Autologous mixed lymphocyte reaction in man. XIII. Characterization of the T-T autologous mixed lymphocyte reaction

Content Provider	Semantic Scholar
Author	Gupta, Sudhir Chandy, K. George Thornton, M. Goldberg, Michelle
Copyright Year	2004
Abstract	In this study we have demonstrated that in the T-TA autologous mixed lymphocyte reaction (AMLR), OKT4+ T cells are the major responders; however, in the presence of additional interleukin-2 (IL-2), OKT8+ T cells also respond by proliferation. Both OKT4+ and OKT8+ T cells, activated in the T-non-T AMLR, act as stimulators in the T-TA AMLR. OKT4+ T cells activated in the T-TA AMLR suppress the proliferative response of the fresh T-non-T AMLR; control OKT4+ cells show no immunoregulatory activity in this system. In contrast, control OKT8+ T cells spontaneously suppress the proliferation of the T-non-T AMLR, but activation of OKT8+ T cells in the T-TA AMLR does not result in a further increase in the suppressor activity of OKT8+ T cells. In summary, in the T-non-T and T-TA AMLR phenotypically similar T-cell subpopulations proliferate but express distinct immunoregulatory functions and perhaps regulate the tempo of the AMLR.
Starting Page	187
Ending Page	194
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1007/BF00915510
PubMed reference number	3159748
Journal	Medline
Volume Number	5
Alternate Webpage(s)	https://page-one.springer.com/pdf/preview/10.1007/BF00915510
Alternate Webpage(s)	https://doi.org/10.1007/BF00915510
Journal	Journal of Clinical Immunology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article