NDLI: Cellulose alters the expression of nuclear factor kappa B-related genes and Toll-like receptor-related genes in human peripheral blood mononuclear cells

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Cellulose alters the expression of nuclear factor kappa B-related genes and Toll-like receptor-related genes in human peripheral blood mononuclear cells

Content Provider	Semantic Scholar
Author	Vogt, Leonie M. Vos, Paul De
Copyright Year	2015
Abstract	The immunomodulatory and epithelial barrier effects of cellulose as a dietary fibre were studied to analyse the potential for use in health promoting functional foods. Reporter assays demonstrated cellulose-mediated activation through TLR/MyD88 dependent-, and independent pathways.Microchip analysis of human PBMCs showed that cellulose induced upregulation of three NF-κB related genes, i.e. CD40 molecule, interleukin 1 receptor antagonist (IL-1Ra), and interleukin-1 receptor-associated kinase 1 (IRAK1). Five upregulated genes related specifically to TLR signalling were identified, i.e. interleukin 1 receptor antagonist (IL-1Ra), interleukin-1 receptor-associated kinase 1 (IRAK1), jun proto-oncogene, mitogen-activated protein kinase kinase 3 (MAP2K3), and mitogen-activated protein kinase 13 (MAPK13). Cellulose did not affect T84 intestinal epithelial cell resistance. Cellulose does not directly affect T84 cell barrier function. However, it alters gene expression in human immune cells and activates TLR and non-TLR related pattern recognition pathways, indicating the immunomodulatory potential of cellulose as major component of root pulp byproduct. © 2015 Elsevier Ltd. All rights reserved.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.rug.nl/research/pathology/medbiol/pdf/leoniejfunctionalfoods2015.pdf
Language	English
Access Restriction	Open
Subject Keyword	Activation function Barrier function CD40 Antigens Cell signaling Cellulose Dental Pulp F Factor Gene Expression IRAK1 protein, human Integrated circuit Interleukin Receptor Common gamma Subunit Interleukin-1 Receptor-Associated Kinases MAP2K3 gene Mitogen-Activated Protein Kinase Kinases Mitogen-Activated Protein Kinases Mitogens Oncogenes Pattern recognition Peripheral blood mononuclear cell (cell) Protein family Receptors, Interleukin-1 Recombinant Interleukins TLR4 protein, human Up-Regulation (Physiology) biological signaling erbB-2 Receptor
Content Type	Text
Resource Type	Article

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