NDLI: Nuevos Aspectos en el Tratamiento de la Diabetes Mellitus Tipo 2

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Nuevos Aspectos en el Tratamiento de la Diabetes Mellitus Tipo 2

Content Provider	Semantic Scholar
Author	Contreras, Freddy Jimenez, Sara García, María Angeles Rocafull, Jorge Montero, Erika Guadalupe Bolon González, Mirían Ospino, Néstor Rodríguez, Solangel Fouilloux, Chistiam Bolivar, Alvaro Lezama, Yurima Velasco, Manuel
Copyright Year	2001
Abstract	La Diabetes Mellitus es una de las enfermedades mas frecuentes en todo el mundo y un problema de salud publica debido a sus complicaciones cronicas y agudas. En los Estados Unidos, actualmente se encuentran en el mercado, cinco tipos de agentes orales cada uno con un mecanismo diferente de accion para mejorar el control glucemico en pacientes con diabetes tipo 2. El Estudio Prospectivo sobre Diabetes concluido en el Reino Unido (UKPDS), ha demostrado que la diabetes mellitus tipo 2 es un desorden progresivo que puede ser tratado inicialmente con monoterapia con un agente oral y eventualmente requiere la adicion de otros agentes orales, y que en muchos pacientes se requiere la terapia con insulina para lograr los niveles glucemicos deseados. En el UKPDS, el control glucemico mejorado, independientemente del agente utilizado (sulfonilureas, biguanidas o insulina), disminuyo la incidencia de complicaciones microvasculares (retinopatia, neuropatia y nefropatia) y macrovasculares. Esta revision examina la terapia antihiperglucemica y el mecanismo de accion, eficacia y los beneficios no-glucemicos de los cinco tipos de agentes orales de uso en la actualidad. ABSTRACT Diabetes mellitus is one of the most frequent diseases all over the world and is a public health problem due its acute and chronic complications. Actually, there are five different oral drugs regarding glycemic control in Type 2 Diabetes available in the United States, each one with a distinct mechanism of action. The finished United Kingdom Prospective Diabetes Study (UKPDS), has demonstrated that Type 2 Diabetes is a progressive disorder that can be initially treated with an oral agent monoterapy, but eventually will require the addition of another agent, and in many patients, will be needed insulin therapy to achieve satisfactory glycemic levels. In the UKPDS the improved glycemic control, unrelated of the employed agent (sulfonylureas, biguanides or insulin), diminished the incidence of microvascular (retinopathy, neuropathy and nephropathy) and macrovascular complications. This review examines the antithyperglycemic therapy and mechanism of action, efficacy, and the non-glycemic benefits of the five oral agents actually in use.
Starting Page	6
Ending Page	26
Page Count	21
File Format	PDF HTM / HTML
Volume Number	20
Alternate Webpage(s)	http://saber.ucv.ve/ojs/index.php/rev_aavft/article/download/7704/7626
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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