Characterization of T cells that are activated after depletion of major encephalitogenic T cells in rat autoimmune encephalomyelitis

Content Provider	Semantic Scholar
Author	Matsumoto, Yoh Jee, Youngheun
Copyright Year	2001
Abstract	In rat experimental autoimmune encephalomyelitis (EAE), encephalitogenic T cells mainly use Vbeta8.2 of TCR, but it is not clear whether Vbeta8.2 is the sole encephalitogenic TCR. To address this issue, we examined the immunological status of Lewis rats that had been treated with anti-Vbeta8.2 mAb and immunized with myelin basic protein (MBP). It was demonstrated that rats in which the majority of Vbeta8.2+ T cells had been depleted developed clinical EAE and possessed newly expanded Vbeta10. Analysis of T cell lines established from these animals revealed that T line cells responded to a minor epitope in the MBP molecule. However, treatment with a mixture of anti-Vbeta8.2 and anti-Vbeta10 mAbs reduced the clinical severity of EAE but did not induce complete suppression of the disease due to new activation of Vbeta6. These findings suggest that rapid and frequent examination of the TCR repertoire is essential to identify pathogenic TCRs and to establish TCR-based immunotherapy for autoimmune diseases.
Starting Page	89
Ending Page	98
Page Count	10
File Format	PDF HTM / HTML
DOI	10.1016/S0165-5728(00)00432-X
PubMed reference number	11240019
Journal	Medline
Volume Number	114
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S016557280000432X
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S016557280000432X?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/S0165-5728%2800%2900432-X
Journal	Journal of Neuroimmunology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article