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Risk of urinary tract cancers following kidney or ureter stones.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chow, W. H. Lindblad, P. A. B. Gridley, Gloria Nyrén, Olof Mclaughlin, Joseph K. Linet, Martha S. Pennello, Gene A. Adami, H. O. Fraumeni, Joseph F. Jr. |
| Copyright Year | 1997 |
| Abstract | BACKGROUND A relationship has been suggested between kidney or ureter stones and the development of urinary tract cancers. In this study, a population-based cohort of patients hospitalized for kidney or ureter stones in Sweden was followed for up to 25 years to examine subsequent risks for developing renal cell, renal pelvis/ureter, or bladder cancer. METHODS Data from the national Swedish In-patient Register and the national Swedish Cancer Registry were linked to follow 61,144 patients who were hospitalized for kidney or ureter stones from 1965 through 1983. Standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) were computed on the basis of nationwide cancer incidence rates, after adjustment for age, sex, and calendar year. RESULTS Risk of renal cell cancer was not elevated in this cohort. Significant excesses of renal pelvis/ureter cancer (SIR = 2.5; 95% CI = 1.8-3.3) and bladder cancer (SIR = 1.4; 95% CI = 1.3-1.6) were observed, but the SIRs for women were more than twice those for men. Risks varied little by age or duration of follow-up. Risks of renal pelvis/ureter cancer and bladder cancer among patients with an associated diagnosis of urinary tract infection were more than double those among patients without such infection, although the risks were significantly elevated in both groups. CONCLUSIONS Individuals hospitalized for kidney or ureter stones are at increased risk of developing renal pelvis/ureter or bladder cancer, even beyond 10 years of follow-up. Chronic irritation and infection may play a role, since kidney or ureter stones were located on the same side of the body as the tumors in most patients with renal pelvis/ureter cancer evaluated in our study. |
| Starting Page | 126 |
| Ending Page | 129 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/jnci/89/19/10.1093_jnci_89.19.1453/2/89-19-1453.pdf?Expires=1492075095&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=Umrj66ae6WEJJ-XXpqvmsuGTHUJD-Mav7SNpNZgriKFKvwW~n22G5a6z9D-9jUl10SeGuxE2cUj8p9RSMQwNxx1OL1KxSI4v56PS2Pqi8UmYK55EqDd23J4ldYcEmFpcLKrgDJ8Y4y4uOvT6Hki-fcG0n-k1NkUGofEZjMEGkFdskQKHSdb16iRhiFI4FcgUMPXYKwbMWGFr0b7qGK7-ywOsqbdD692DBKyj-a-pA6x2G~WRR5uWEkrrI-uTPw4TC0eraNdN1kNKI--HhPNW8INWm2B2Gu~kfUZgaj4AAZcGJcu76rCtcazOGrI9-kUjus6TK~pd7FEoLn0iTQ5YZg__ |
| PubMed reference number | 9326915v1 |
| Volume Number | 89 |
| Issue Number | 19 |
| Journal | Journal of the National Cancer Institute |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Bladder Neoplasm Calculi Cancer Registry Cancer of Urinary Tract Confidence Intervals Epithelial cell of renal tubule Kidney Diseases Kidney Failure, Chronic Malignant neoplasm of ureter Neoplasms Patients Renal Cell Carcinoma Renal Tissue Renal pelvis Systemic Inflammatory Response Syndrome Ureteral duplication Urinary tract infection |
| Content Type | Text |
| Resource Type | Article |
