NDLI: Biology, role and therapeutic potential of circulating histones in acute inflammatory disorders

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Biology, role and therapeutic potential of circulating histones in acute inflammatory disorders

Content Provider	Semantic Scholar
Author	Szatmary, Peter Huang, Wei Criddle, David Neil Tepikin, Alexei V. Sutton, Robert
Copyright Year	2018
Abstract	Histones are positively charged nuclear proteins that facilitate packaging of DNA into nucleosomes common to all eukaryotic cells. Upon cell injury or cell signalling processes, histones are released passively through cell necrosis or actively from immune cells as part of extracellular traps. Extracellular histones function as microbicidal proteins and are pro-thrombotic, limiting spread of infection or isolating areas of injury to allow for immune cell infiltration, clearance of infection and initiation of tissue regeneration and repair. Histone toxicity, however, is not specific to microbes and contributes to tissue and end-organ injury, which in cases of systemic inflammation may lead to organ failure and death. This review details the processes of histones release in acute inflammation, the mechanisms of histone-related tissue toxicity and current and future strategies for therapy targeting histones in acute inflammatory diseases.
Starting Page	4617
Ending Page	4629
Page Count	13
File Format	PDF HTM / HTML
PubMed reference number	30085397v1
Alternate Webpage(s)	https://doi.org/10.1111/jcmm.13797
DOI	10.1111/jcmm.13797
Journal	Journal of cellular and molecular medicine
Volume Number	22
Language	English
Access Restriction	Open
Subject Keyword	Adverse reaction to drug Cessation of life Charge (electrical) Diffuse Scleroderma Extracellular Traps Histones Leukemia, Myelocytic, Acute Liver Failure, Acute Necrosis Nuclear Proteins Nucleosomes Transcription Initiation biological signaling cellular targeting
Content Type	Text
Resource Type	Article

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