NDLI: Fos imaging reveals that lesions of the anterior thalamic nuclei produce widespread limbic hypoactivity in rats.

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Fos imaging reveals that lesions of the anterior thalamic nuclei produce widespread limbic hypoactivity in rats.

Content Provider	Semantic Scholar
Author	Jenkins, Trisha Anne Dias, Rebecca
Copyright Year	2002
Abstract	Activity of the immediate early gene c-fos was compared in rats with neurotoxic lesions of the anterior thalamic nuclei and in surgical controls. Fos levels were measured after rats had been placed in a novel room and allowed to run up and down preselected arms of a radial maze. An additional control group showed that in normal rats, this exposure to a novel room leads to a Fos increase in a number of structures, including the anterior thalamic nuclei and hippocampus. In contrast, rats with anterior thalamic lesions were found to have significantly less Fos-positive cells in an array of sites, including the hippocampus (dorsal and ventral), retrosplenial cortex, anterior cingulate cortex, and prelimbic cortex. These results show that anterior thalamic lesions disrupt multiple limbic brain regions, producing hypoactivity in sites associated in rats with spatial memory. Because many of the same sites are implicated in memory processes in humans (e.g., the hippocampus and retrosplenial cortex), this hypoactivity might contribute to diencephalic amnesia.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://orca.cf.ac.uk/3253/1/JENKINS__Orca3253.pdf
Alternate Webpage(s)	http://orca-mwe.cf.ac.uk/3253/1/JENKINS__Orca3253.pdf
Alternate Webpage(s)	http://psych.cf.ac.uk/home2/aggleton/The%20J%20Neurosci%20-%2022%20-%205230-5238.pdf
Alternate Webpage(s)	http://www.jneurosci.org/content/22/12/5230.full.pdf
PubMed reference number	12077218v1
Volume Number	22
Issue Number	12
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Language	English
Access Restriction	Open
Subject Keyword	Alveolar rhabdomyosarcoma Amnesia Anterior Nuclear Group Cingulate Cortex FOS gene Limbic Encephalitis Memory Disorders Neurotoxicity Syndromes Thalamic Nuclei Thalamic structure
Content Type	Text
Resource Type	Article

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