NDLI: Sequence-Dependent Structural Stability of Self-Assembled Cylindrical Nanofibers by Peptide Amphiphiles.

Please wait, while we are loading the content...

Sequence-Dependent Structural Stability of Self-Assembled Cylindrical Nanofibers by Peptide Amphiphiles.

Content Provider	Semantic Scholar
Author	Fu, Iris Nguyen, Hung
Copyright Year	2015
Abstract	Three-dimensional networks of nanofibers, which are formed through self-assembly of peptide amphiphiles, serve as a biomimetic hydrogel scaffold for tissue engineering. With an emphasis to improve hydrogel properties for cell-specific behavior, a better understanding between structural characteristics and physical properties of the macroscopic gel is sought. Large-scale molecular dynamics simulations were performed on two PA sequences with identical composition (palmitoyl-V3A3E3 and palmitoyl-A3V3E3) showing different self-assembly kinetic mechanisms. While both sequences yielded cylindrical nanofibers, these structures have contrasting internal arrangement with respect to the hydrophobic core; the former is continuous with predominately alkyl tails, whereas the latter is disjointed with interconnecting micelles. Two additional sequences (palmitoyl-V6E3 and palmitoyl-A6E3) were examined to determine the effects of a homogeneous β-sheet forming segment that is either strongly or mildly hydrophobic on self-assembly. Results from this study indicate that internal structural arrangement of nanofibers can provide a correlation with structural stability and mechanical behavior of hydrogel nanostructures.
Starting Page	1
Ending Page	12
Page Count	12
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://cloudfront.escholarship.org/dist/prd/content/qt7qq8r6p2/qt7qq8r6p2.pdf?t=nu0c5t
PubMed reference number	26068113v1
Alternate Webpage(s)	https://doi.org/10.1021/acs.biomac.5b00595
DOI	10.1021/acs.biomac.5b00595
Journal	Biomacromolecules
Volume Number	16
Issue Number	7
Language	English
Access Restriction	Open
Subject Keyword	Biomimetics Hydrogel Kinetics Molecular Dynamics Nanofibers Nanostructured Materials Palmitoyl-CoA Hydrolase Physical Phenomenon or Property Tail Tissue Engineering alkyl diacylglycerol O-acyltransferase
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in