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Mu opioid receptors in developing human spinal cord.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ray, Subrata Basu Wadhwa, Shashi |
| Copyright Year | 1999 |
| Abstract | The distribution of mu opioid receptors was studied in human fetal spinal cords between 12-13 and 24-25 wk gestational ages. Autoradiographic localisation using [3H] DAMGO revealed the presence of mu receptors in the dorsal horn at all age groups with a higher density in the superficial laminae (I-II). A biphasic expression was noted. Receptor density increased in the dorsal horn, including the superficial laminae, between 12-13 and 16-17 wk. This could be associated with a spurt in neurogenesis. The density increased again at 24-25 wk in laminae I-II which resembled the adult pattern of distribution. A dramatic proliferation of cells was noted from the region of the ventricular zone between 16-17 and 24-25 wk. These were considered to be glial cells from their histological features. Mu receptor expression was noted over a large area of the spinal cord including the lateral funiculus at 24-25 wk. This may be due to receptor expression by glial cells. The study presents evidence of mu receptor expression by both neurons and glia during early development of human spinal cord. |
| Starting Page | 218 |
| Ending Page | 218 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://static.cambridge.org/resource/id/urn:cambridge.org:id:binary:20170213064934105-0768:S0021878299004963:S002187829900496Xa.pdf |
| PubMed reference number | 10473288v1 |
| Volume Number | 195 |
| Part | 1 |
| Journal | Journal of anatomy |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Gestational Age Neurogenesis Neuroglia Opioid Receptor Receptors, Opioid, mu Receptors, Serotonin, 5-HT2 Structure of posterior gray horn of spinal cord establishment and maintenance of localization |
| Content Type | Text |
| Resource Type | Article |
