NDLI: Molecularly Imprinted Polymers Used as Optical Waveguides for the Detection of Fluorescent Analytes

Content Provider	Semantic Scholar
Author	Brazier, Jennifer J. Yan, Mingdi Prahl, Scott A. Chen, Yin-Chu
Copyright Year	2002
Abstract	Abstract : This article demonstrates the novel approach of fabricating molecularly imprinted polymers (MIPs) as fiber optic waveguides for the detection of fluorescent analytes. Combining a polyurethane system and the soft lithography technique of micromolding in capillaries (MIMIC), polymer waveguides of 50 micrometers and 100 micrometers dimensions were patterned onto a silicon substrate. Laser coupling into small waveguide segments has been verified visually. Binding experiments using the waveguides are currently being explored. Some preliminary binding studies have been performed, however, for smaller, freestanding filaments of sizes consistent with conventionally prepared MIP particles. Using fluorimetry measurements, templated fibers of 20 micrometers dimension preferentially bound the analyte molecules by a factor of 1.5 as compared to control polymers.
File Format	PDF HTM / HTML
DOI	10.1557/PROC-723-M6.4
Volume Number	723
Alternate Webpage(s)	https://apps.dtic.mil/dtic/tr/fulltext/u2/p013610.pdf
Alternate Webpage(s)	https://omlc.org/~prahl/pubs/pdf/brazier02a.pdf
Alternate Webpage(s)	http://www.dtic.mil/get-tr-doc/pdf?AD=ADP013610
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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