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Effects of transdermally delivered insulin on some selected metabolic parameters of streptozotocin-induced diabetic male Sprague-Dawley rats
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hadebe, Silindile Innocentia Ngubane, Phikelelani Siphosethu. Serumula, Metse R. Musabayane, Cephas T. |
| Copyright Year | 2014 |
| Abstract | Untreated STZ-induced diabetic rats exhibited extensive hyperglycaemia, depletion of liver and muscle glycogen concentrations by the end of the 5-week experimental period (Figure 3 and Table 2). The reduction in glycogen production was associated with decreased expressions of the insulin-stimulated glycogen synthase (GS) and facilitative glucose transporter (GLUT4) in hepatic and skeletal muscle tissues, respectively. Treatment with s.c. insulin (175 μg/ kg) and various doses of topically applied PI hydrogel matrix patch for 5 weeks restored the expression of GLUT-4 and GS to levels that were comparable to the non-diabetic control animals (Figure 4). |
| File Format | PDF HTM / HTML |
| DOI | 10.1530/endoabs.34.P203 |
| Alternate Webpage(s) | https://www.endocrine-abstracts.org/ea/0034/eposters/ea0034p203_eposter.pdf |
| Alternate Webpage(s) | https://doi.org/10.1530/endoabs.34.P203 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
