Stereochemistry of internucleotide bond formation by the H -phosphonate method. 2. Transesterification of aryl ribonucleoside H -phosphonate diesters with alcohols

Content Provider	Semantic Scholar
Author	Sobkowski, Michal Jankowska, Jadwiga Stawinski, Jacek Kraszewski, Adam
Copyright Year	2005
Abstract	Aryl ribonucleoside 3’-H-phosphonates were used as model compounds in investigations of stereochemistry of an internucleotide bond formation. For all four ribonucleoside 3’-H-phosphonates studied the major diastereomers of the produced H-phosphonate diesters were found to be formed from the minor diastereomers of nucleoside aryl H-phosphonate diesters. These studies indicate the importance of an equilibrium between substrate diastereomers and can be relevant to the stereoselectivity observed in condensation reactions of ribonucleoside H-phosphonates promoted by condensing agents, e.g. pivaloyl chloride.
Starting Page	183
Ending Page	187
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1135/css200507183
Volume Number	7
Alternate Webpage(s)	http://users.man.poznan.pl/msob/Transesterification%20of%20aryl%20ribonucleoside%20H-phosphonate.pdf
Alternate Webpage(s)	https://doi.org/10.1135/css200507183
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article