NDLI: Neuronal activity up-regulates astroglial gene expression.

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Neuronal activity up-regulates astroglial gene expression.

Content Provider	Semantic Scholar
Author	Steward, Oswald Torre, Enrique De La Tomasulo, Richard A. Lothman, E. W.
Copyright Year	1991
Abstract	Neuronal gene expression is known to be modulated by functional activity. This modulation is thought to play a key role in determining the differentiation of developing neurons and regulating the operation of mature neurons. Here we describe a regulation of astroglial gene expression by neuronal activity. We report that intense neuronal activity (electrically induced seizures) in rat hippocampus leads to rapid and dramatic increases in mRNA for glial fibrillary acidic protein (GFAP), an astroglia-specific intermediate filament protein. GFAP mRNA levels increased at sites of stimulation as well as in areas that were synaptically activated by the resultant seizures. When seizures were induced repetitively for many days, levels of GFAP mRNA remained chronically elevated. However, GFAP mRNA returned to control levels within a few days after the cessation of stimulation. The coupling between astroglial gene expression and neuronal activity may be a mechanism through which neuronal activity modulates the function of supporting cells that are responsible for regulating the extracellular microenvironment of the brain.
Starting Page	18
Ending Page	25
Page Count	8
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.pnas.org/content/88/15/6819.full.pdf
PubMed reference number	1862105v1
Volume Number	88
Issue Number	15
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Subject Keyword	Acids Astrocytes Cytoskeletal Filaments Electricity GFAP gene Gene Expression Glial Fibrillary Acidic Protein Intermediate Filaments Neuroglia Seizures
Content Type	Text
Resource Type	Article

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