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Active internal re-warming using a centrifugal pump and heat exchanger following haemorrhagic shock, surgical trauma and hypothermia in a porcine model.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Garraway, Naisan Robert Brown, David Ross Kirkpatrick, Andrew B. Schneidereit, Nathan P. Heest, Rardi D. Van Hwang, Hamish Simons, Richard |
| Copyright Year | 2007 |
| Abstract | BACKGROUND The centrifugal vortex blood pump (CVBP) using heparin-bonded circuitry allows re-warming of hypothermic trauma patients without anticoagulation. Study objectives were to confirm efficacy, and to characterise the physiology of CVBP re-warming in a porcine model. METHODS Sixteen pigs were randomised to conventional or CVBP re-warming. They were bled to a mean arterial pressure of 30 mmHg and cooled to 29 degrees C. A physiological analysis was recorded during resuscitation to normo-tension and re-warming back to 37 degrees C. RESULTS CVBP animals re-warmed significantly faster: 85.0+16.4 min versus 217.4+49.3 min (p<0.0001). Activated clotting time was significantly elevated in both groups at 29 degrees C with a marked trend to normalise faster in CVBP pigs. The peak cardiac index (CI) was significantly lower (1.14+0.68 versus 4.83+1.50 L/(min m2), while the systemic vascular resistance (SVR) was significantly higher (4239.9+1173.0 versus 1472.6+451.2 dyn x S x m2/cm5) with CVBP (p<0.001). CONCLUSION CVBP is simple and very effective at re-warming hypothermic animals and may also reverse coagulopathy more quickly. Physiological derangements of elevated SVR and diminished CI require further study to elaborate underlying aetiology, and define optimal re-warming strategies. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.ubccriticalcaremedicine.ca/academic/jc_article/Active%20internal%20rewarming%20in%20trauma%202007%20(Feb-14-08).pdf |
| PubMed reference number | 17585913v1 |
| Volume Number | 38 |
| Issue Number | 9 |
| Journal | Injury |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Blood Coagulation Disorders Cumulative Trauma Disorders Dyne - unit of force Heat Stress Disorders Hematological Disease Hypothermia due to exposure Mastocytosis, Systemic Patients Porcine species Resuscitation procedure Shock, Hemorrhagic Shock, Surgical Tension Total Peripheral Resistance Wounds and Injuries heparin physiological aspects torr |
| Content Type | Text |
| Resource Type | Article |
