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La adicción a la nicotina: vulnerabilidad, epigénesis y modelos animales de estudio
| Content Provider | Semantic Scholar |
|---|---|
| Author | Pastor, Verónica Vazquez, Pablo Raul Ruisenor Corapi, Enrique Sebastian Bernabeu, Ramón |
| Copyright Year | 2013 |
| Abstract | Este articulo es un resumen de las investigaciones actuales sobre los efectos de la nicotina en el sistema nervioso y su relacion con la generacion de una conducta adictiva. Al igual que otros psicoestimulantes, la nicotina activa la via de la recompensa, la que tambien esta involucrada en ciertas enfermedades psiquiatricas. Existen individuos que presentan una alta vulnerabilidad a volverse adictos a la nicotina. Esto puede deberse a factores tanto geneticos como epigeneticos y/o al entorno. En este trabajo se describen algunos factores epigeneticos implicados en estos fenomenos. Para este tipo de estudios, existen dos modelos comportamentales en animales: la autoadministracion y el condicionamiento al lugar (CPP). Aqui, el CPP se explica en detalle por su potencial aplicacion en humanos. Ademas, se describe la determinacion comportamental de la actividad locomotora (lo cual indica el efecto causado por un psicoestimulante) como modelo para estudiar la vulnerabilidad individual a las drogas. Palabras claves:Adiccion a la Nicotina; Condicionamiento Clasico; Epigenesis; Vulnerabilidad. Nicotine addiction: studies about vulnerability, epigenesis and animal models: This article is a summary about the current research of nicotine effects on the nervous system and its relationship to the generation of an addictive behavior. Like other drugs of abuse, nicotine activates the reward pathway, which in turn is involved in certain psychiatric diseases. There are individuals who have a high vulnerability to nicotine addiction. This may be due to genetic and epigenetic factors and/or the environment. In this review, we described some epigenetic factors that may be involved in those phenomena. The two animal models most widely used for studying the reinforcing effects of nicotine are: self-administration and conditioning place preference (CPP). Here, we emphasized the CPP, due to its potential application in humans. In addition, we described the locomotor activity model (as a measure of psychostimulant effects) to study vulnerability to drugs of abuse. Key Words: Nicotine Addiction; Classical Conditioning; Epigenesis; Vulnerability. /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} |
| Starting Page | 61 |
| Ending Page | 73 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| DOI | 10.32348/1852.4206.v5.n2.5148 |
| Volume Number | 5 |
| Alternate Webpage(s) | https://revistas.unc.edu.ar/index.php/racc/article/download/5148/5314 |
| Alternate Webpage(s) | http://ri.conicet.gov.ar/bitstream/handle/11336/1748/7_RACC_Vol_5_N-_2_Pastor_61-73.pdf?isAllowed=y&sequence=1 |
| Alternate Webpage(s) | https://doi.org/10.32348/1852.4206.v5.n2.5148 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
