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Improved diabetic control in insulin-dependent diabetics treated with insulin and glibenclamide.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Waterfield, M. R. |
| Copyright Year | 1984 |
| Abstract | A randomized double blind trial of insulin and glibenclamide treatment vs insulin and placebo was carried out in 20 insulin-dependent diabetics. Nine patients were C-peptide secretors and all increased their C-peptide output during a 50 g OGTT at the end of the insulin and glibenclamide treatment period by a mean of 47%. At the same time their mean daily blood glucose fell from 8.4 +/- 1.7 to 7.4 +/- 1.5 mmol/l and their HbA1 from 8.1 +/- 0.5 to 7.5 +/- 0.9% (mean +/- SD). There was no change in any of the measurements of diabetic control in C-peptide non-secretors and no evidence for any extra-pancreatic effects of glibenclamide in this group of patients. Combined insulin and glibenclamide treatment may produce a useful improvement of diabetic control in insulin-dependent diabetics who still secrete some endogenous insulin, although further studies are required. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://eje.bioscientifica.com/downloadpdf/journals/eje/107/1/acta_107_1_011.pdf |
| PubMed reference number | 6435371v1 |
| Volume Number | 107 |
| Issue Number | 1 |
| Journal | Acta endocrinologica |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | C-Peptide DNA Breaks, Double-Stranded Diabetes Mellitus Glucose Glyburide Glycosylated hemoglobin A Hematological Disease Millimole per Liter Patients Physiological Sexual Disorders |
| Content Type | Text |
| Resource Type | Article |
