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Microwave-assisted Synthesis, characterization and antimicrobial evaluation of some new tetrazolo[1,5-a] quinoline based benzimidazoles catalyzed by an organocatalyst p-TsOH
| Content Provider | Semantic Scholar |
|---|---|
| Author | Darji, Ketan Patel, Jiten C. Patel, Kamalkumar S. Dholariya, Hitesh R. Patel, Vishal K. Patel |
| Copyright Year | 2012 |
| Abstract | Co(II), Ni(II), Cu(II) and Mn(II) complexes synthe sized by reflux of 6bromo-3-(3-(4-chlorophenyl)acryloyl)-2Hchromen-2one, Ciprofloxacin and various transition metal. 1H, 13C, IR and ESI Mass confirm the formation of ligand. The metal complexes were characterized on the basis of various spectroscopic techniques like IR studies and elemental analysis while the ge om try of complexes was octahedral which is confirmed by electronic spectra and thermogravim-etric analysis. The compounds were subjected to antimicrobial, anti oxidant and anti-tubercular activity screening using serial broth dilution meth od and Minimum Inhibitory Concentration (MIC) is determined. Mn(II) complex h as shown significant antifungal activity with an MIC of 6.25 μg/ml while Cu(II) complex is noticeable for antibacterial activity at the same concentration. A ti-TB activity of the ligand has enhanced on complexation with Ni(II) and Co(II) ion s. While Ni(II) complex shows superior antioxidant activity than other complexes. List of Publications Sardar Patel University 200 | P a g e INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL SCIENCES 2012, 1(2), 83–88 ISSN No.: 2278-0564 Publisher: IJHPS Synthesis, electronic spectra and antimicrobial significance of novel drug based complexes G.R. Chauhan, K. D. Patel, H.R. Dholariya, J.C. Patel and K.K. Tiwari Sophisticated Instrumentation Centre for Applied Research & Testing (SICART), Vallabh Vidyanagar-388 120, Gujarat, India V. P. & R. P. T. P. Science College, Sardar Patel University, Vallabh Vidyanagar 388 120, Gujarat, India ABSTRACT Mixed-ligand complexes of the transition metal ion s Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) with the clioquinol and 8-hydroxy quinoline derivative have been prepared. The coordination behaviour of the mixed-l igand complexes was characterized on the basis of elemental analyses, I R, and electronic spectra. The magnetic measurements have been obtained by a vibra ting sample magnetometer. It is observed that the mixed-ligand complexes of Mn(II), Co(II), Ni(II) and Cu(II) are paramagnetic, while the Zn(II) complexes is diamagn etic. All of these mixed-ligand complexes are coloured crystalline solids. Octahedr al geometries have been assigned to all of the prepared mixed-ligand complexes. The antibacterial activities of the ligands, the metal chlorides, the mixed-ligand comp lexes, the standard drug (clioquinol) and control (dimethyl sulfoxide) was t es ed on the pathogenic bacteria S. typhi, E. coli, and Serratia marcescens using the “disc diffusion method” and the results are discussed.Mixed-ligand complexes of the transition metal ion s Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) with the clioquinol and 8-hydroxy quinoline derivative have been prepared. The coordination behaviour of the mixed-l igand complexes was characterized on the basis of elemental analyses, I R, and electronic spectra. The magnetic measurements have been obtained by a vibra ting sample magnetometer. It is observed that the mixed-ligand complexes of Mn(II), Co(II), Ni(II) and Cu(II) are paramagnetic, while the Zn(II) complexes is diamagn etic. All of these mixed-ligand complexes are coloured crystalline solids. Octahedr al geometries have been assigned to all of the prepared mixed-ligand complexes. The antibacterial activities of the ligands, the metal chlorides, the mixed-ligand comp lexes, the standard drug (clioquinol) and control (dimethyl sulfoxide) was t es ed on the pathogenic bacteria S. typhi, E. coli, and Serratia marcescens using the “disc diffusion method” and the results are discussed. List of Publications Sardar Patel University 201 | P a g e ALFA UNIVERSAL: AN INTERNATIONAL JOURNAL OF CHEMISTRY 2012, 3(2), 57–64 ISSN No.: 2229-4775 Publisher: Alfa Universal Mechanical, thermal and improved fire retardant properties of reinforced polymer composite T.K. Darji, J.C. Patel, K.S. Patel, H.R. Dholariya, Vishal K. Patel and K. D. Patel* V. P. & R. P. T. P. Science College, Sardar Patel University, Vallabh Vidyanagar 388 120, Gujarat, India Chemistry Department, Shree P. M. Patel College of Peramedical Science & Technology, Sardar Patel University, Gujarat, India ABSTRACT Unsaturated polyester resin has been synthesized us ing pentandiol, maleicanhydride and adipic acid. Synthesized unsaturated polyester resin, glass fiber and different fillers along with benzoyl peroxide as catalyst wer e used for the composite preparation. Mechanical, thermal and improve fire r etardant properties of composites were evaluated. The results indicate the good therm al stability of all compounds. Composites having flourpar shows good fire retardan t properties.Unsaturated polyester resin has been synthesized us ing pentandiol, maleicanhydride and adipic acid. Synthesized unsaturated polyester resin, glass fiber and different fillers along with benzoyl peroxide as catalyst wer e used for the composite preparation. Mechanical, thermal and improve fire r etardant properties of composites were evaluated. The results indicate the good therm al stability of all compounds. Composites having flourpar shows good fire retardan t properties. List of Publications Sardar Patel University 202 | P a g e SYNTHESIS AND REACTIVITY IN INORGANIC, METAL-ORGANIC AND NANO-METAL CHEMISTRY ACCEPTED M.S. No.: LSRT-2009-0038 ISSN No: 1553-3182 Impact Factor: 0.56 (2012) Publisher: Taylor & Francis Synthesis, thermal and biological studies of newly synthesized Cu(II) complexes with ciprofloxacin based on bromo-coumarins derivatives K.S. Patel, J.C. Patel, H.R. Dholariya and K. D. Patel* V. P. & R. P. T. P. Science College, Sardar Patel University, Vallabh Vidyanagar 388 120, Gujarat, India Abstract In present work we describe synthesis, characteriza ion nd biological evaluation of Cu(II) complexes. Characterization of ligands has been carried out by elemental analysis, melting point, mass spectra, ( H & C) NMR, and FT-IR, while structure of metal complexes were confirmed by electronic spectr a and FAB-mass spectral studies. Spectral studies confirm ligands is mono f unctional bidentate and octahedral environment around metal ions. Thermal behaviour of Cu(II) complexes were investigated by means of TGA, and magnetic measurem ents. The kinetic parameters are reported using the Freeman-Carroll method. Comp lexes were found significant potent antimicrobial and antioxidant activities com pared to parent ligands employed for complexation.In present work we describe synthesis, characteriza ion nd biological evaluation of Cu(II) complexes. Characterization of ligands has been carried out by elemental analysis, melting point, mass spectra, ( H & C) NMR, and FT-IR, while structure of metal complexes were confirmed by electronic spectr a and FAB-mass spectral studies. Spectral studies confirm ligands is mono f unctional bidentate and octahedral environment around metal ions. Thermal behaviour of Cu(II) complexes were investigated by means of TGA, and magnetic measurem ents. The kinetic parameters are reported using the Freeman-Carroll method. Comp lexes were found significant potent antimicrobial and antioxidant activities com pared to parent ligands employed for complexation. List of Publications Sardar Patel University 203 | P a g e MEDICINAL CHEMISTRY RESEARCH Communicated ISSN No: 1554-8120 Impact Factor: 1.271 (2012) Publisher: Springer Thermal, kinetic, spectroscopic studies and antimicrobial, anti-tuberculosis, antioxidant properties of clioquinol and benzo-coumarin derivatives mixed complexes with copper |
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| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
