NDLI: Responder cells in the human autologous mixed lymphocyte reaction.

Content Provider	Semantic Scholar
Author	Smolen, Josef S. Luger, Thomas Anton Chused, Thomas M. Steinberg, Alfred D.
Copyright Year	1981
Abstract	Isolated human T4+ cells proliferate in the autologous mixed lymphocyte reaction (AMLR), whereas isolated T8+ cells do not. However, in the presence of Interleukin 2 or T4+ cells, the T8+ cells demonstrated substantial proliferation. These studies suggest that T8+ cells recognize signals from autologous non-T cells, but require an additional factor for the subsequent proliferative response. Since this stimulus can be provided by T4+ cells, the AMLR appears to constitute an inducer circuit. Different defects in this circuit may be responsible for the common abnormality of the AMLR in different diseases.
File Format	PDF HTM / HTML
DOI	10.1172/JCI110416
PubMed reference number	6459343
Journal	Medline
Volume Number	68
Issue Number	6
Alternate Webpage(s)	http://dm5migu4zj3pb.cloudfront.net/manuscripts/110000/110416/JCI81110416.pdf
Alternate Webpage(s)	https://doi.org/10.1172/JCI110416
Journal	The Journal of clinical investigation
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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