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The RSK factors of activating the Ras/MAPK signaling cascade.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Carrière, A. Ray, Hind Blenis, John Roux, Philippe P. |
| Copyright Year | 2008 |
| Abstract | The p90 ribosomal S6 kinase (RSK) constitute a family of serine/threonine kinases activated downstream of the Ras/mitogen-activated protein kinase (MAPK) pathway. In mammals, four RSK genes have been identified (RSK1, RSK2, RSK3 and RSK4), and RSK orthologues have also been described in D. melanogaster and C. elegans, but not in yeast or plants. The RSK isoforms are composed of two distinct and functional kinase domains that are activated in a sequential manner by a series of phosphorylation events. These enzymes were among the first substrates of extracellular signal-regulated kinase (ERK) to be discovered and have proven to be ubiquitous and multifunctional mediators of ERK signal transduction. While the RSK isoforms promote cell survival though the inactivation of several apoptotic effectors, they also appear to mediate cell growth and proliferation by simultaneously regulating substrates involved in gene transcription and mRNA translation. RSK1-4 are ubiquitously expressed in cell lines and tissues, and at present, little is known about specific and overlapping functions of individual RSK isoforms. The upregulation of RSK1 and RSK2 expression in different types of cancer suggest that they may be involved in oncogenesis and could potentially be targeted in anti-cancer therapies. The recent identification of specific RSK inhibitors will likely help addressing the biological functions of the RSK isoforms and their contributions in pathological conditions. |
| Starting Page | 4176 |
| Ending Page | 4177 |
| Page Count | 2 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.roux.iric.ca/PDF%20papers/FBS%202008%20-%20RSK%20review.pdf |
| Alternate Webpage(s) | https://www.bioscience.org/fbs/getfile.php?FileName=/2008/v13/af/3003/3003.pdf |
| PubMed reference number | 18508509v1 |
| Volume Number | 13 |
| Journal | Frontiers in bioscience : a journal and virtual library |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Body tissue Cascade Device Component Cell Survival Cultured Cell Line Mammals Mitogen-Activated Protein Kinases Mitogens Neoplasms Non-Small Cell Lung Carcinoma Protein Isoforms RPS6KA1 gene RPS6KA1 wt Allele RPS6KA2 gene RPS6KA3 gene RPS6KA6 gene Ribosomal Protein S6 Kinase Signal Transduction Threonine Transcription, Genetic cell growth eIF-2 Kinase |
| Content Type | Text |
| Resource Type | Article |
