NDLI: Restricted expression of measles virus proteins in brains from cases of subacute sclerosing panencephalitis.

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Restricted expression of measles virus proteins in brains from cases of subacute sclerosing panencephalitis.

Content Provider	Semantic Scholar
Author	Liebert, Uwe Gerd Baczko, Knut Budka, H. Meulen, Volker Ter
Copyright Year	1986
Abstract	The presence of five structural proteins of measles virus in brain material obtained at autopsy from four patients with subacute sclerosing panencephalitis (SSPE) was examined by immunofluorescence employing monoclonal antibodies. In addition, the humoral immune response against measles virus antigens in serum and cerebrospinal fluid was analysed by immunoprecipitation in combination with gel electrophoresis, revealing a reduced response mainly to the matrix (M) protein. In none of the brain material were all five structural proteins simultaneously detected. Nucleocapsid protein and phosphoprotein were found in every diseased brain area, whereas haemagglutinin (H) protein was detected in two, fusion (F) protein in three and M protein only in one SSPE case. In two cases, variations in the occurrence of H and F proteins could be observed between regions displaying different degrees of neuropathological changes. No correlation was observed between the humoral immune response and the immunohistological findings. These data support the hypothesis of a restricted synthesis of measles virus proteins, in particular the envelope and M proteins, in SSPE.
File Format	PDF HTM / HTML
DOI	10.1099/0022-1317-67-11-2435
PubMed reference number	3537205
Journal	Medline
Volume Number	67
Part	11
Alternate Webpage(s)	https://www.microbiologyresearch.org/docserver/fulltext/jgv/67/11/JV0670112435.pdf?accname=guest&checksum=9FE826048ABEF30CF3FD1945D52C8E24&expires=1545940616&id=id
Alternate Webpage(s)	http://www.microbiologyresearch.org/docserver/fulltext/jgv/67/11/JV0670112435.pdf?accname=guest&checksum=2D7E68CED3E70E2B740AE7E05C5BEA48&expires=1541833095&id=id
Alternate Webpage(s)	https://doi.org/10.1099/0022-1317-67-11-2435
Journal	The Journal of general virology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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