NDLI: Vesicular zinc regulates the Ca2+ sensitivity of a subpopulation of presynaptic vesicles at hippocampal mossy fiber terminals.

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Vesicular zinc regulates the Ca2+ sensitivity of a subpopulation of presynaptic vesicles at hippocampal mossy fiber terminals.

Content Provider	Semantic Scholar
Author	Lavoie, Nathalie Jeyaraju, Danny Vijey Peralta, Modesto R. Seress, L. Ászló Pellegrini, Luca Tóth, Katalin
Copyright Year	2011
Abstract	Synaptic vesicles segregate into functionally diverse subpopulations within presynaptic terminals, yet there is no information about how this may occur. Here we demonstrate that a distinct subgroup of vesicles within individual glutamatergic, mossy fiber terminals contain vesicular zinc that is critical for the rapid release of a subgroup of synaptic vesicles during increased activity in mice. In particular, vesicular zinc dictates the Ca(2+) sensitivity of release during high-frequency firing. Intense synaptic activity alters the subcellular distribution of zinc in presynaptic terminals and decreases the number of zinc-containing vesicles. Zinc staining also appears in endosomes, an observation that is consistent with the preferential replenishment of zinc-enriched vesicles by bulk endocytosis. We propose that functionally diverse vesicle pools with unique membrane protein composition support different modes of transmission and are generated via distinct recycling pathways.
Starting Page	445
Ending Page	450
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/31/50/18251.full.pdf
PubMed reference number	22171030v1
Alternate Webpage(s)	https://doi.org/10.1523/JNEUROSCI.4164-11.2011
DOI	10.1523/jneurosci.4164-11.2011
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume Number	31
Issue Number	50
Language	English
Access Restriction	Open
Subject Keyword	Endosomes Hippocampus (Brain) Membrane Proteins Mossy Fibers, Hippocampal Presynaptic Terminals Subgroup A Nepoviruses Synaptic Vesicles Tissue fiber Vesicle (morphologic abnormality) mossy fiber
Content Type	Text
Resource Type	Article

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