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Performance of an exhaled nitric oxide and carbon dioxide sensor using quantum cascade laser-based integrated cavity output spectroscopy.
| Content Provider | Semantic Scholar |
|---|---|
| Author | McCurdy, Matthew Riegel Bakhirkin, Yury A. Wysocki, Gerard Tittel, Frank K. |
| Copyright Year | 2007 |
| Abstract | Exhaled nitric oxide (NO) is an important biomarker in asthma and other respiratory disorders. The optical performance of a NOCO(2) sensor employing integrated cavity output spectroscopy (ICOS) with a quantum cascade laser operating at 5.22 microm capable of real-time NO and CO(2) measurements in a single breath cycle is reported. A NO noise-equivalent concentration of 0.4 ppb within a 1-sec integration time is achieved. The off-axis ICOS sensor performance is compared to a chemiluminescent NO analyzer and a nondispersive infrared (NDIR) CO(2) absorption capnograph. Differences between the gas analyzers are assessed by the Bland-Altman method to estimate the expected variability between the gas sensors. The off-axis ICOS sensor measurements are in good agreement with the data acquired with the two commercial gas analyzers. This work demonstrates the performance characteristics and merits of mid-infrared spectroscopy for exhaled breath analysis. |
| Starting Page | 034034 |
| Ending Page | 034034 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| DOI | 10.1117/1.2747608 |
| Alternate Webpage(s) | http://lasersci.rice.edu/files/2014/05/93.-JBO-McCurdy-June-2007.pdf |
| Alternate Webpage(s) | http://www.ece.rice.edu/~lasersci/93.%20JBO%20McCurdy%20June%202007.pdf |
| Alternate Webpage(s) | https://www.spiedigitallibrary.org/journals/Journal-of-Biomedical-Optics/volume-12/issue-03/034034/Performance-of-an-exhaled-nitric-oxide-and-carbon-dioxide-sensor/10.1117/1.2747608.pdf |
| Alternate Webpage(s) | https://www.spiedigitallibrary.org/journalIssue/Download?DOI=10.1117/1.2747608&downloadType=journal+article&fullDOI=10.1117/1.2747608&isResultClick=True |
| Alternate Webpage(s) | https://astronomicaltelescopes.spiedigitallibrary.org/journalArticle/Download?fullDOI=10.1117/1.2747608&isResultClick=False |
| Alternate Webpage(s) | https://www.spiedigitallibrary.org/journalArticle/Download?fullDOI=10.1117/1.2747608&isResultClick=False |
| PubMed reference number | 17614742 |
| Alternate Webpage(s) | https://doi.org/10.1117/1.2747608 |
| Journal | Medline |
| Volume Number | 12 |
| Issue Number | 3 |
| Journal | Journal of biomedical optics |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
