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FA5-MS38: Current trends in protein and small molecules crystallization and monitoring
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wiesmann, Joerg Michaelsen, Carsten Graf, Jürgen Blagova, A. Kovalchuka, M. V. Prosekova, P. A. Pisarevskija, Yu. V. Ruiza, Juan Manuel García |
| Copyright Year | 2010 |
| Abstract | Modern microfocus X-ray sources define the state-of-the-art for a number of applications such as protein crystallography and small-angle scattering in the home lab. These sources have small source sizes of 100 μm or smaller. They are usually combined with multilayer mirrors as beam-shaping devices that image the source spot onto the sample position, magnified to a suitable size, and deliver a parallel or focused monochromatic beam. Microfocusing rotating anode systems deliver flux densities in the range of 10 photons/(s mm) at power loads of up to 20 kW/mm when combined with synthetic multilayer mirrors [1]. However, these sources are expensive, and need regular and sometimes time-consuming maintenance. Low power microfocus sealed tube sources such as the Incoatec Microfocus Source “IμS” represent an interesting low-maintenance alternative to rotating anode generators. Power loads of several kW/mm in anode spot sizes of ≤ 50 μm deliver a small and highly brilliant beam [2]. The IμS delivers a flux density of up to 10 photons/(s mm) in a focused beam (FWHM = 0.11 mm, 7.6 mrad) suitable for most protein crystals. Emerging microfocus X-ray sources based on liquid-metal-jet technologies show even higher power loads up to 500 kW/mm, an order of magnitude higher than possible with solid target sources, and intensities up to 10 photons/(s mm) together with a relatively low power consumption and reduced maintenance [3]. We will present selected results from several microfocus source systems to demonstrate their potential for crystallography and small-angle scattering. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://journals.iucr.org/a/issues/2010/a1/00/a46464/a46464.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
