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Antihyperglycaemic Activity of Ethanol Extract of Helicteres Isora Fruits in Alloxan Induced Diabetic Mice
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bodhankar, Subhash L. Dhaneshwar, Sunil Rajaram |
| Copyright Year | 2008 |
| Abstract | Summary The antihyperglycaemic activity of the ethanol extract of Helicteres isora ( EEHI ) fruits was studied by administering three doses of EEHI (i. e.100, 200 and 400 mg/kg, p. o.) to alloxan (70 mg/kg, i. v.) induced diabetic mice. The serum glucose levels and body weights of mice were determined. The acute oral toxicity study showed no mortality up to 5000 mg/kg p. o. dose of EEHI. In acute study the maximum reduction in serum glucose level was observed at 2h (59.86 mg/dl), peak at 6 h (167.59 mg/dl) but antihyperglycaemic effect was vanished at 24 h (76.99 mg/dl). In glyburide treated mice the reduction in serum glucose level was observed at 2 h (94.04 mg/dl) and peak at 6 h (237.90 mg/dl) respectively. The subacute study was also carried out which showed maximum reduction in serum glucose level (221.42 mg/dl) at the dose of 400 mg/kg on 35th day. In glyburide treated mice maximum reduction in serum glucose level (312.28 mg/dl) was observed on 21 st day. The oral glucose tolerance test (OGTT) was carried out after administration of EEHI in non-diabetic and diabetic mice previously loaded with (2.5 g/kg, p. o.) glucose. EEHI (400 mg/kg) showed increased glucose threshold in non-diabetic and diabetic mice. The EEHI(400 mg/kg) prevented the loss of body weight. These results indicated antihyperglycaemic activity of EEHI (400 mg/kg) in alloxan induced diabetic mice. The antihyperglycaemic activity of EEHI was comparable with glyburide. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://pharmacologyonline.silae.it/files/archives/2008/vol3/083_Sunil.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
