NDLI: Evaluation the effect of Baccaris trimera on parameters of oxidative stress of streptozotocin-induced diabetic rats

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Evaluation the effect of Baccaris trimera on parameters of oxidative stress of streptozotocin-induced diabetic rats

Content Provider	Semantic Scholar
Author	Pedrosa, Guitián Silva
Copyright Year	2012
Abstract	Antioxidant therapy has been used worldwide, aiming to reduce oxidative stress and the complications of diseases like diabetes. Baccharis trimera, commonly known in Brazil as carqueja, is a medicinal plant known by its antioxidants properties and it’s used in popular cultures like antidiabetic. The aim of this study was to evaluate the antioxidant potential of a seven-day treatment with an extract of Baccharis trimera in streptozotocininduced diabetic rats. The antioxidant effects were evaluated by quantifying the levels of thiobarbituric acid reactive substances (TBARS), protein carbonylation, and the activity of catalase and superoxide dismutase (SOD). All assays were measured in liver of 38 male fisher rats distributed in 4 groups (control C, non diabetic treated NDt, diabetic D, diabetic treated Dt). The results were statistical analyzed by Student’s “t” test. P values less than 0.05 were considered significant. Any of the assays realized showed statistical difference between groups, except for the activity of catalase that presented lower levels in treated groups. Catalase activity were significantly lower Dt group (588.1 ± 51.0 μmol/ml) comparing to D group (730.3 ± 80.5 μmol/ml), and in NDt group (816 ± 64 μmol/ml) comparing to C group (940 ± 146.8 μmol/ml). Our study concluded that the seven-day treatment with the extract of Baccharis trimera in male rats is not efficient in the reduction of oxidative stress, and we suggest that more studies should be realized in different experimental models.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.sbbq.org.br/reuniao/cdrom/ra2012/resumos/R9090.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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