NDLI: How to judge animal models of Parkinson's disease in terms of neuroprotection.

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How to judge animal models of Parkinson's disease in terms of neuroprotection.

Content Provider	Semantic Scholar
Copyright Year	2006
Abstract	Ideally, animal models of Parkinson's should reproduce the clinical manifestation of the disease, a loss of some but not all dopaminergic neurons, a loss of some non dopaminergic neurons and alpha-synuclein positive inclusions resembling Lewy bodies. There are at least three ways to develop animal models of PD. The first two are based on the etiology of the disease and consist in 1) reproducing in animals the mutations seen in inherited forms of PD; 2) intoxicating animals with putative environmental toxins causing PD. The last method currently used, which is not exclusive of the first two, is to try to reproduce the molecular or biochemical changes seen post-mortem in the brain of patients with PD. In this review we discuss the advantages and the drawbacks in term of neuroprotection of the currently used models.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://eknygos.lsmuni.lt/springer/340/5.Models/2%20Item.pdf
PubMed reference number	17017538v1
Volume Number	70
Journal	Journal of neural transmission. Supplementum
Language	English
Access Restriction	Open
Subject Keyword	Animal Model Anti-Inflammatory Agents Biologic Preservation Dopamine Hydrochloride Dopaminergic Neurons Inclusion Bodies Lewy Bodies Monoamine Oxidase Mutation Neuroprotection PPAR gamma Parasitic Diseases, Animal Parkinson Disease Parkinsonian Disorders Patients Peroxisome Proliferators Substantia nigra structure Synucleins Toxin alpha-Synuclein pioglitazone
Content Type	Text
Resource Type	Article

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