Multicontrast MRI Quantification of Focal Inflammation and Degeneration in Multiple Sclerosis

Content Provider	Semantic Scholar
Author	Bonnier, Guillaume Roche, Alexis Romascano, David Simioni, Samanta Meskaldji, Djalel Eddine Rotzinger, David C. Lin, Ying-Chia Menegaz, Gloria Schluep, Myriam Pasquier, Renaud Du Sumpf, Tilman J. Frahm, Jens Thiran, Jean-Philippe Krüger, Gunnar Dr. Granziera, Cristina
Copyright Year	2015
Abstract	INTRODUCTION Local microstructural pathology in multiple sclerosis patients might influence their clinical performance. This study applied multicontrast MRI to quantify inflammation and neurodegeneration in MS lesions. We explored the impact of MRI-based lesion pathology in cognition and disability. METHODS 36 relapsing-remitting MS subjects and 18 healthy controls underwent neurological, cognitive, behavioural examinations and 3 T MRI including (i) fluid attenuated inversion recovery, double inversion recovery, and magnetization-prepared gradient echo for lesion count; (ii) T1, T2, and T2(*) relaxometry and magnetisation transfer imaging for lesion tissue characterization. Lesions were classified according to the extent of inflammation/neurodegeneration. A generalized linear model assessed the contribution of lesion groups to clinical performances. RESULTS Four lesion groups were identified and characterized by (1) absence of significant alterations, (2) prevalent inflammation, (3) concomitant inflammation and microdegeneration, and (4) prevalent tissue loss. Groups 1, 3, 4 correlated with general disability (Adj-R (2) = 0.6; P = 0.0005), executive function (Adj-R (2) = 0.5; P = 0.004), verbal memory (Adj-R (2) = 0.4; P = 0.02), and attention (Adj-R (2) = 0.5; P = 0.002). CONCLUSION Multicontrast MRI provides a new approach to infer in vivo histopathology of plaques. Our results support evidence that neurodegeneration is the major determinant of patients' disability and cognitive dysfunction.
File Format	PDF HTM / HTML
DOI	10.1155/2015/569123
PubMed reference number	26295042
Journal	Medline
Volume Number	2015
Alternate Webpage(s)	http://eprints.imtlucca.it/2425/1/BioMed_res_int_Lin_2014.pdf
Alternate Webpage(s)	http://pubman.mpdl.mpg.de/pubman/item/escidoc:2155742/component/escidoc:2155743/2155742.pdf
Alternate Webpage(s)	http://pubman.mpdl.mpg.de/pubman/item/escidoc:2182831/component/escidoc:2182834/2181831_Suppl.pdf?mode=download
Alternate Webpage(s)	http://downloads.hindawi.com/journals/bmri/2015/569123.pdf
Alternate Webpage(s)	http://pubman.mpdl.mpg.de/pubman/item/escidoc:2182831/component/escidoc:2182833/2181831.pdf
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/34/d5/BMRI2015-569123.PMC4532805.pdf
Alternate Webpage(s)	https://doi.org/10.1155/2015%2F569123
Journal	BioMed research international
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article