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olyl vinyl isonitrile synthases in the biogenesis and diversi fi cation of hapalindole-type alkaloids †
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ittiamornkul, Kuljira Gkotsi, Danai S. Smith, Duncan R. M. Hillwig, Matthew L. Nightingale, Nicole Gossb, Rebecca J. M. Liu, Xinyu |
| Copyright Year | 2015 |
| Abstract | The hapalindole-type alkaloids naturally show striking late stage diversification of what was believed to be a conserved intermediate, cis-indolyl vinyl isonitrile (1a). Here we demonstrate enzymatically, as well as through applying a synthetic biology approach, that the pathway generating 1a (itself, a potent natural broad-spectrum antibiotic) is also dramatically flexible. We harness this to enable early stage diversification of the natural product and generation of a wide range of halo-analogues of 1a. This approach allows the preparatively useful generation of a series of antibiotics with increased lipophilicity over that of the parent antibiotic. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://pubs.rsc.org/en/content/articlepdf/2015/sc/c5sc02919h |
| Alternate Webpage(s) | https://research-repository.st-andrews.ac.uk/bitstream/handle/10023/7655/Goss_2015_SC_Promiscuous_CC.pdf;jsessionid=57A54E048B0D02F37680D2872ADC04BF?sequence=1 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
